Male reproductive genetic profile


Men with a sperm count less than 5 million/ml may carry a chromosomal abnormality. A karyotype test (chromosome analysis) is carried out to ensure  the karyotype is normal (46 XY)

An abnormal karyotype can be associated with infertility, miscarriage or foetal abnormality. Some of the abnormal karyotype necessitate Pre-implantation genetic diagnosis (PGD) during the IVF cycle in order to avoid having a baby with a chromosomal abnormality and reduce the risk of miscarriage.


Y chromosome analysis

Men with a sperm count less than 5 million/ml may also have a problem with the AZF genes on the Y chromosome. This test may influence the decision on whether or not to perform surgical sperm retrieval.


Cystic fibrosis screen (CFTR gene tests)

Mutations of the cystic fibrosis gene are involved in male infertility. Some causes of male infertility such as absence of the vas deferens are considered to be mild forms of cystic fibrosis disease.

It is important to screen the female partner of the affected male for CFTR gene mutations. If the female partner is found to be a carrier of a CFTR gene mutation, Pre-implantation genetic diagnosis (PGD) is necessary to avoid having a child with cystic fibrosis disease.


Contact us

If you would like to book an appointment with one of our doctors you can:

  • Speak to the booking team on +44 (0)20 7837 2905  (Mon – Fri 8.30am – 6pm)
  • Email us on 
  • Visit our Appointments page, fill out the contact form and a member of the team will be in touch.

IVF Packages With Access Fertility

IVF Packages With Access Fertility
CRGH is partnering with Access Fertility to offer a series of IVF programmes and packages. For more information please click below.

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