What Is IMSI in IVF Treatment?
Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) with IVF is an advanced technique used in fertility treatment where powerful magnification is used to select the sperm with the best size and shape to inject into the egg.
There is some limited evidence to suggest that by selecting the sperm with the best morphology, pregnancy rates might be improved and miscarriage rates are reduced. However, as research continues, there is not yet conclusive evidence as to the benefits of IMSI during the IVF process.
IMSI can be used when sperm quality or morphology is sub-optimal, allowing the embryologist to select the best sperm with which to fertilise the egg. IMSI is similar to Intracytoplasmic Sperm Injection (ICSI); the latter is often combined with Preimplantation Genetic Diagnosis (PGD) or testing for aneuploidy (screening for numerical chromosomal abnormalities).
As IMSI is classed as an Add On by the HFEA, it will be recommended if deemed to reduce the chances of miscarriage or implantation failure.
Our Outstanding Success Rates
IVF with IMSI/PIMSI Live Birth Rates, Per Embryo Transferred, 2021
Live Birth Rate per embryo transferred in under 35s
2022
42.9%
Live Birth Rate per embryo transferred all ages average
2022
31.0%
Our consultants are experts at understanding your previous medical and fertility history, as well as your goals for treatment, and will be able to provide options based on your unique fertility journey.
Frequently Asked Questions
The process of IVF with IMSI
How long does IVF with Intracytoplasmic Morphologically Selected Sperm Injection take?
Using IMSI doesn’t usually impact the typical timeline for a cycle of IVF treatment, which usually takes around six weeks. This estimate can vary for different individuals, and is often governed by menstrual cycles.
Is IVF with IMSI suitable for everyone?
IVF with IMSI is considered an Add On, and therefore is only offered to those for whom it is deemed relevant. This can include those who have previously had an unsuccessful implantation or miscarriage.
Is IVF with IMSI safe?
IVF with IMSI comes with certain risks that are still being researched, and should be taken into consideration. For example, there is a very small risk that the egg may be damaged during the injection process.
Your consultant will explain these risks and the measures we take to avoid them. You can read more about the risks below, or visit the HFEA website which explains the risks for IVF and all other fertility treatments available in the UK.
Can you use donated sperm or eggs for IVF with IMSI?
Yes, you can use donated egg or sperm in IVF with IMSI. Our specialist team can help you find appropriate donated gametes.
You can learn more about IVF with donated eggs and IVF with donated sperm on our website.
Can you pause during the IVF with IMSI process?
Yes, with IVF you are generally able to “pause” at certain points in the process, and using an Intracytoplasmic Morphologically Selected Sperm Injection does not affect this. This can be helpful for those who have other commitments.
Speak to your consultant for more information on how to schedule your treatment.
How much does IVF with IMSI cost?
We tailor your treatment at every stage to ensure you have the best possible chance of success. Treatment costs will vary depending on your individual needs, particularly when it comes to medication, so prior to starting treatment, our finance team will provide you with an itemised costing of your unique treatment plan.
• Ovarian hyperstimulation syndrome (OHSS)
• Multiple births (twins or triplets)
• Ectopic pregnancy
Your consultant will discuss these risks, and how we avoid them, during your consultation.
IMSI is deemed an Add On by the HFEA; you can learn more about the risks associated with all fertility treatment available in the UK on the HFEA website.
