Research & publications

Below is a list of academic publications that our specialists have contributed to:

A retrospective case series of clinical application of karyomapping for couples requiring preimplantationgenetic diagnosis.

Ben-Nagi J., Doye K, Wells D, Exeter H, Drew W, Serhal P. : ESHRE 2016, Helsinki

Trophectoderm biopsy and transfer in a subsequent frozen thaw embryo replacement cycle in preimplantation genetic diagnosis cycles

Karen Doye, Jara Ben Nagi, Kalliopi E. Loutradi, Emily Drew, Holly Exeter, Paul Serhal: ESHRE 2016, Helsinki Download here

Preconceptual health and fertility treatment – an evidence based approach

E. Chronopoulou1 , P Serhal, S. Seshadri: ESHRE 2016, Helsinki

Outcomes of blastocyst transfer using vitrified donor oocytes

W Saab, S Seshadri, M Davies, A Petrie, H Exeter, P Serhal:  ESHRE 2016, Helsinki

Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer

Wuntakal R, SeshadriS, Montes A, Lane G. CochraneDatabaseof SystematicReviews 2016, Issue 6. Art. No.: CD011322. DOI: 10.1002/14651858.CD011322.pub2.

Preimplantation genetic diagnosis: an overview and recent advances

Ben-Nagi J, Serhal P, SenGupta S, Doye K, Wells D. Preimplantation genetic diagnosis: an overview and recent advances. The Obstetrician & Gynaecologist 2016;18:99106. DOI:10.1111/tog.12264

The origin and significance of additional aneuploidy events in couples undergoing preimplantation genetic diagnosis for translocations by array comparative genomic hybridization.

Ghevaria H, SenGupta S, Shmitova N, Serhal P, Delhanty J: Reproductive biomedicine online 32.2 (2016): 178-189.

Effect of progesterone levels on clinical pregnancy rates in IVF/ICSI cycles

S Seshadri, M Bhargava, A Doshi, W Saab, P serhal: BFS Annual Meeting 2016, Gateshead

Report of a Viable Pregnancy Arising from a Zygote with a Single Pronucleus at 16 Hours Post Inseminatation.

Hema Sarna, Alpesh Doshi, Suzanne Cawood, Urvashi Sarna, Anastasia Mania, Rabi Odia, Paul Serhal. Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here

Data Analysis to Determine Whether There is an Association Between the Day of Blastocyst Formation and Sex Ratio.

Hema Sarna, Paul Serhal, Kalliopi Loutradi, Anastasia Mania and Ozkan Ozturk.  Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here

Does Multinucleation Correlate to Direct and Reverse Cleavage in Day 2 Cleavage Stage Embryos? A Time-lapse Analysis.

A. Mania, L. Papaioannou, V. Wigley, U. Sarna, C. Heath, S. Gotts, K. Loutradi, A. Doshi, W. Saab, P. Serhal. Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here

Should cryopreservation of sperm be routinely offered to Klinefelter’s patients?

Emily Drew, Suzanne Cawood, Alpesh Doshi, Paul Serhal. Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here

Investigation of microRNA expression and DNA repair gene transcripts in human oocytes and blastocysts.

Tulay, P., Naja, R. P., Cascales-Roman, O., Doshi, A., Serhal, P., & SenGupta, S. B. (2015). Journal of assisted reproduction and genetics32(12), 1757-1764.

Successful outcomes achieved in assisted reproduction cycles using sperm with high levels of high DNA stainability

Speyer, B. E., Pizzey, A. R., Abramov, B., Saab, W., Doshi, A., Sarna, U., … & Serhal, P. (2015).Systems biology in reproductive medicine61(5), 293-299.

Karyomapping: A novel alternative approach to PGD

S Seshadri, J Ben Nagi, K Doye, W Saab, A Doshi, D Wells, P Serhal:  ESHRE 2015, Lisbon

Adequate luteal support in Frozen embryo transfer cycles: Natural or Artificial Intramuscular progesterone?

A Al-Chami, S Salim, H Skye, A Doshi, W Saab, S Seshadri, P Serhal: BFS Annual Meeting 2015, Birmingham

Telomere length in human blastocysts.

Mania, A., Mantzouratou, A., Delhanty, J. D., Baio, G., Serhal, P., & Sengupta, S. B. (2014). Reproductive biomedicine online28(5), 624-637.

Factors influencing the outcome of intrauterine insemination (IUI): age, clinical variables and significant thresholds.

Speyer BE, Abramov B, Saab W, Doshi A, Sarna U, Harper JC, Serhal P.; Obstet Gynaecol. 2013 Oct;33(7):697-700. doi: 10.3109/01443615.2013.810199.

Role of Insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries.

Stubbs SA, Webber LJ, Stark J, Rice S, Margara R, Lavery S, Trew GH, Hardy K, Franks S. J Clin Endocrinol Metab. 2013 Aug;98(8):3298-305. doi: 10.1210/jc.2013-1378.

Hepcidin levels in diabetes mellitus and polycystic ovary syndrome.

Sam AH, Busbridge M, Amin A, Webber L, White D, Franks S, Martin NM, Sleeth M, Ismail NA, Daud NM, Papamargaritis D, Le Roux CW, Chapman RS, Frost G, Bloom SR, Murphy KG. Diabet Med. 2013 Dec;30(12):1495-9. doi: 10.1111/dme.12262.

Prepregnancy care.

Seshadri S, Oakeshott P, Nelson-Piercy C, Chappell LC. BMJ. 2012 May 31;344:e3467. doi: 10.1136/bmj.e3467.

Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters.

Joharatnam J, Barber TM, Webber L, Conway GS, McCarthy MI, Franks S. Clin Endocrinol (Oxf). 2011 Jun;74(6):714-9

The importance of the early uterine environment on obstetric outcome in ART treatments.

Cawood S, Harper J, Serhal P, Joshi R, Doshi A. (2011). 6th Institute for Women’s Health, UCL.

Data analysis of patients suitable for elective single embryo transfer: why are patient’s refusing?

Cawood S, Gotts S, Harper J, Serhal P, Doshi A. (2011) P33 6th Institute for Women’s Health, UCL.

Does assisted hatching improve the clinical outcome in vitrified-warmed embryo cycles?

Cawood S, Doshi A, Gotts S, Serhal P. (2011). Fertility 2011, 5th-7th January/ Reproductive BioMedicine Online 20 Suppl. 2 (2010) S47–S49. Abstract FC-4 Alpha 2010, 8th Biennial conference, Budapest, Hungary, 30th April-2nd May.

A clinical pregnancy after transfer of a single vitrified warmed blastocyst derived from a donor vitrified-warmed oocyte.

Cawood S, Doshi A, Serhal P, Harper J. (2011). P109 Fertility 2011, 5th-7th January.

Vitrified vs. slow-frozen blastocysts: A clinical audit for 706 embryos.

Cawood S, Doshi A, Gotts S (2010). Reproductive BioMedicine Online 20 Suppl. 2 (2010) S47–S49. Abstract FC-2 Alpha, 2010, 8th Biennial conference, Budapest, Hungary, 30th April-2nd May/ Hum. Reprod. 25 (suppl 1): i170-i210. Abstract of the 26th Annual Meeting of the European Society of Human Reproduction and Embryology, Rome, Italy, 27-30 June.

Infertility (The Facts).

Oxford University Press, 2009
Melanie Davies, Lisa Webber, Caroline Overton

Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries.

Franks S, Webber LJ, Goh M, Valentine A, White DM, Conway G, Wiltshire S & McCarthy M J Clin Endocrinol Metab. 2008 Sept; 93: (9) 3396-3402

Response to controlled ovarian stimulation and oocyte quality in women with myotonic dystrophy type I. Journal of Assisted Reproduction Genetics.

Vol 25 (Issue 1): pp 1-5, B Sahu, O Ozturk, N Deo, K Fordham, DM Ranieri, P Serhal (2008)

Comparison of oocyte quality and intracytoplasmic sperm injection outcome in women with isolated polycystic ovaries or polycystic ovarian syndrome.

Archives Gynecology Obstetrics. Vol 277 (Number 3) : pp 239-44
B Sahu, O Ozturk, DM Ranieri, P Serhal (2008)

Evaluation of the relationship between follicular fluid oxidative stress, ovarian hormones, and response to gonadotropin stimulation. Fertility and Sterility. Vol. 89 (issue 4) : pp 912-21

M Appasamy, E Jauniaux, P Serhal, A Al-Qahtani, NP Groome, S Muttukrishna (2008)

Prolonged survival in culture of preantral follicles from polycystic ovaries.

Webber LJ, Stubbs SA, Stark J, Margara RA, Trew GH, Lavery SA, Hardy K, Franks S. J Clin Endocrinol Metab. 2007 May;92(5):1975-8. Epub 2007 Mar 6.

Disordered follicle development in ovaries of prenatally androgenized ewes.

Forsdike RA, Hardy K, Bull L, Stark J, Webber LJ, Stubbs S, Robinson JE, Franks S. J Endocrinol. 2007 Feb;192(2):421-8.

Preimplantation genetic diagnosis for myotonic dystrophy type 1
in the UK.

Neuromuscular Disorders , Vol 18 (Issue 2) : pp 131 – 136
G Kakourou, S Dhanjal, T Mamas, S Gotts, A Doshi, K Fordham, P Serhal, DM Ranieri, JD Delhanty, JC Harper, SB SenGupta (2007)

Variable aneuploidy mechanisms in embryos from couples with poor reproductive histories undergoing preimplantation genetic screening. Human Reproduction. Vol 22 (issue 7) : pp 1844-53

A Mantzouratou, A Mania, E Fragouli, L Xanthopoulou, S Tashkandi, K Fordham, DM Ranieri, A Doshi, S Nuttall, JC Harper, P Serhal, JD Delhanty (2007)

Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility. Reproductive Biomedicine Online. Feb;14(2):159-65.

M Appasamy, S Muttukrishna, AR Pizzey, O Ozturk, NP Groome, P Serhal, E Jauniaux (2007) www.ncbi.nlm.nih.gov/pubmed/17298717?dopt=AbstractPlus

Preimplantation genetic diagnosis for retinoblastoma predisposition British Journal of Ophthalmology 91: 1090-1091

S Dhanjal, G Kakourou, T Mamas, N Saleh, A Doshi, S Gotts, S Nuttall, K Fordham, P Serhal, J Delhanty, JC Harper and S SenGupta (2007)

Premimplantation Genetic Diagnosis for myotonic dystrophy type 1: detection of cross-over between the gene and the linked marker AP0C2. Prenatal Diagnosis, 27 (2): 111-116

G Kakourou, S Dhanjal, Daphnis, A Doshi, S Nuttall, S Gotts, P Serhal, J Delhanty, JC Harper, and S SenGupta (2007)

Variations in Humanized and Defined Culture Conditions Supporting Derivation of New Human Embryonic Stem Cell Lines. Cloning and Stem Cells. December 1, 2006, 8(4): 319-334. doi:10.1089/clo.2006.8.319.

Judy M. Fletcher, Patricia M. Ferrier, John O. Gardner, Linda Harkness, Seema Dhanjal, Paul Serhal, Joyce Harper, Joy Delhanty, David G. Brownstein, Yogesh R. Prasad, Jane Lebkowski, Ram Mandalam, Ian Wilmut, Paul A. De Sousa

Comparative Genomic Hybridisation analysis of human occytes and polar bodies. Human Reproduction 21: 2319-2328.

E Fgagouli, D Wells, A Thornhill, P Serhal, MJW Faed, JC Harper, JDA Delhanty (2006)

Anti-Mullerian hormone (AMH) protein expression is reduced during the initial stages of follicle development in human polycystic ovaries

S Stubbs, K Hardy, P Da Silva-Buttkus, J Stark, LJ Webber, A Flanagan, APN Themmen, JA Visser, NP Groome, & S Franks
Journal of Clinical Endocrinology & Metabolism 2005 Oct 90(10):5536-5543

Antral Follicle count,anti-mullerian hormone and inhibinB: predictors of ovarian response in assisted reproductive technology?

S. Muttukrishmna, H. McGarrigle, R. Wakim, I. Khadum, D.M. Ranieri and P. Serhal. BJOG , Vol.112,.2005

Good Clinical Practice in Assisted Reproduction:

Ed. Paul Serhal and Caroline Overton. Camb. Univ.Press. 2004.

Formation and early development of follicles in the polycystic ovary

LJ Webber, S Stubbs, J Stark, GH Trew, R Margara, K Hardy & S Franks, The Lancet 2003; 362:1017-1021

Cervical dilatation with hygroscopic rods prior to ovarian
stimulation facilitates embryo transfer.

Paul Serhal, Domenico Massimo Ranieri, Iffat Khadum and Rami Antoine Wakim. Human Reproduction, Vol. 18, No.12 pp 2618-2620, 2003.

Preimplantation genetic diagnosis of chromosome abnormalities: implications from the outcome for couples with chromosomal rearrangements.

M.Simopoulou, J.C.Harper, E.Fragouli, A.Mantzouratou, B.E.Speyer, P.Serhal, D.M.Ranieri, A.Doshi, J.Henderson, C.H.Rodeck and J.D.A.Delhanty. Prenat.Diagn. 2003: 23: 652-662.

Cytogenetic and Y chromosome microdeletion screening of a random group of infertile males.

C.R. Quilter, E.C. Svennevik, P. Serhal, D. Ralph, G. Bahadur, R. Stanhope, M. Sutterlin, J. Delhanty and K.E. Taylor. Fertility and Sterility Vol. 79 No. 2 February 2003.

A comparative study between infertile males and patients with Turner Syndrome to determine the influence of sex chromosome mosaicism and the breakpoints of structurally abnormal Y chromosomes on phenotypic sex.

C.R. Quilter, N. Nathwani, G.S.Conway, R.Stanhope, D. Ralph, G. Bahadur, P. Serhal, K. Taylor and J.D.A. Delhanty. Journal of Medical Genetics 2002; 39; e80-e80.

Ovarian response and in vitro fertilisation outcome in patients with reduced ovarian reserve who were stimulated with recombinant follicle-stimulating hormone or human menopausal gonadotropin.

F. Meo, D.M. Ranieri, I. Khadum, P. Serhal. Fertility & Sterility Vol. 77 No. 3. March 2002.

First application of preimplantation genetic diagnosis to neurofibromatosis type 2 (NF2)

Abou-Sleiman P MN, Apessos A, Harper JC, Serhal P, Winston R M, Delhanty J. Prenat. Diagn. 2002 Jun; 22 (6): 519-24.

PGD for Single Gene Disorders: Experience with five single gene disorders, myotonic dystrophy, two mutations for cystic fibrosis, simultaneous diagnosis of fragile X and CF, Crouzon Syndrome and Neurofibromatosis type 2 Prenatal Diagnosis, 22 (6): 525-533

Joyce C. Harper, Dagan Wells, Wirawit Piyamongkol, Patrick Abou-Sleiman, Angela Apessos, Antonis Ioulianis, Mary Davis, Alpesh Doshi, Paul Serhal, Massimo Ranieri, Charles Rodeck and Joy D.A. Delhanty (2002)

Preimplantation Genetics and Diagnosis Paper

First application of preimplantation genetic diagnosis to neurofibromatosis type 2 (NF2)
P. M. Abou-Sleiman, A. Apessos, J. C. Harper , P. Serhal, R. M. L. Winston , J. D. A. Delhanty (2002)

Pregnancy Following Preimplantation Genetic Diagnosis for Crouzon Syndrome.

P.M. Abou-Sleiman, A. Apessos, J.C. Harper, P.Serhal and J.D.A. Delhanty. Molecular Human Reproduction, 8, 101-104. 2002.

Pregnancy Following Preimplantation Genetic Diagnosis for Crouzon Syndrome.

P.M. Abou-Sleiman, A. Apessos, J.C. Harper, P.Serhal and J.D.A. Delhanty. Molecular Human Reproduction, 8, 101-104. 2002.

A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR.

W. Piyamongkol, J.C. Harper, J.K. Sherlock, A. Doshi, P.F. Serhal, J.D.A. Delhanty and D. Wells. Prenat Diagn 2001; 21: 223-232.

Simultaneous evaluation of basal FSH and oestradiol response to GnRH analogue (G-G-Test) allows effective drug regimen selection for IVF.

D.M.Ranieri, P.Phophong, I. Khadum, F. Meo, C. Davis and P.Serhal. Human Reprod. 2001 Vol. 16 No.4 pp 673-675.

Clinical aspects of preimplantation diagnosis.

C.Overton, P.Serhal, M.Davies Chapter in Preimplantation Genetic Diagnosis. Eds.: J. Harper, J.Delhanty and A.Handyside. 2001

Basal 17 B-estradiol did not correlate with ovarian response and in vitro fertilization treatment outcome.

P.Phophong, d.M. Ranieri, I. Khadum, F. Meo, and P. Serhal. Fertility & Sterility Vol. 74 No. 6 2000. pp 1133-36

FISH analysis on day 5 post-insemination of human arrested and blastocyst stage embryos.

P.Ruangvutilert, J.D.A. Delhanty, P. Serhal, Mara Simopoulou, Charles H. Rodeck and Joyce C. Harper. Prenat Diagn 2000: 20: 552-560

Ovarian reserve: A simple mathematical problem?

D.M.Ranieri, P.Serhal. Human. Reprod. 2000. 15: 1423-4.