Research & publications

Below is a list of academic and research publications to which our fertility specialists at CRGH have contributed:

Adding a low-quality blastocyst to a high-quality blastocyst for a double embryo transfer does not decrease pregnancy and live birth rate. Theodorou E, Jones BP, Cawood S, Heath C, Serhal P, Ben-Nagi J. Acta Obstet Gynecol Scand. 2021 Jun;100(6):1124-1131
Chromosome Y as a marker for sex discrepancies in patients with organ transplants: a case report Nuria Balaguer, Emilia Mateu-Brull, Roy P. Naja, Jara Ben Nagi, Miguel Milán Mol Cytogenet. 2021; 14: 3
Pre-implantation genetic testing for aneuploidy: motivations, concerns, and perceptions in a UK population Benjamin P. Jones, Timothy Bracewell-Milnes, Lorraine Kasaven, Ariadne L’Heveder, Megan Spearman, Diana Marcus, Maria Jalmbrant, Joy Green, Rabi Odia, Srdjan Saso, Paul Serhal, Jara Ben Nagi J Assist Reprod Genet. 2021 Aug; 38(8): 1987–1996
Male translocations in Recurrent Pregnancy Loss: Natural conception versus PGD treatment: what is the right option? A systematic review and meta-analysis.
Cardenas, D; Odia, R; Yasmin, E; Serhal, P; Saab, W; Seshadri, S. ESHRE Oral Presentation 2021
Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis. Guy Morris 1 2, Dimitrios Mavrelos 1 2, Rabi Odia 1, Xavier Viñals Gonzalez 1, Suzanne Cawood 1, Ephia Yasmin 1 2, Wael Saab 1, Paul Serhal 1, Srividya Seshadri 1. 2021
Pre-implantation genetic testing for aneuploidy; motivations, concerns and perceptions in a UK population. Benjamin P Jones 1 2, Timothy Bracewell-Milnes 3, Lorraine Kasaven 4, Ariadne L’Heveder 4, Megan Spearman 5, Diana Marcus 4 3, Maria Jalmbrant 4, Joy Green 5, Rabi Odia 5, Srdjan Saso 4 3, Paul Serhal 5, Jara Ben Nagi 5. 2021
Adding a low quality blastocyst to a high quality blastocyst for a double embryo transfer does not decrease pregnancy and live birth rate. Efstathios Theodorou 1, Benjamin P Jones 2 3, Suzanne Cawood 1, Carleen Heath 1, Paul Serhal 1, Jara Ben-Nagi 1 3. 2021
The First Livebirth Using Warmed Oocytes by a Semi-Automated Vitrification. Xavier Orriols Brunetti (, Suzanne Cawood, Matthew Gaunt, Wael Saab, Paul Serhal, Srividya Seshadri. 2021
Chromosomal Analysis of Cumulus Cells as a Future Predictor for Oocyte Aneuploidy: A Case Report. Xavier Viñals Gonzalez , Rabi Ahmed-Odia , Sioban Sen Gupta , Roy Pascal Naja , Falak Arshad , Paul Serhal , Srividya Seshadri. 2021
Simple and complex aneuploidy in premeiotic oocytes detected by aCGH & NGS : evidence for genetic influence and effect on fertility. H. Ghevaria, S. SenGupta, R. Naja, R. Odia, P. Serhal, X. Gonzalez, X. Sun, J. Delhanty Poster presentation: 2021
Imaging comprehensive algorithm of reproductive efficiency (i-CARE), a ranking tool for human oocyte competence. Xavier Vinals Gonzalez; Christopher Thrasivoulou; Matthew Gaunt; Srividya Seshadri; Paul Serhal; Sioban Sen Gupta. Fertility 2021, Oral.
Oocyte competence: determined or modifiable? Emilia Foster, Roy Naja, Harita Ghevaria, Joy Delhanty, Paul Serhal, Sioban Sen Gupta, Xavier Viñals Gonzalez. E-Poster, Fertility 2021
Preimplantation Genetic Testing for Aneuploidy: Current Perspectives. L’Heveder A, Jones BP, Naja R, Serhal P, Nagi Ben J.Semin Reprod Med. 2021 Mar;39(1-02):1-12.
Oocyte yield in social, medical and donor oocyte cryopreservation cycles. Ben-Nagi J, Kasaven LS, Jones BP, Saso S, Norris G, Green J, Petrie A, Odia R, Serhal P, Yasmin E. Hum Fertil (Camb). 2020 Dec 3:1-13
Perceptions, outcomes, and regret following social egg freezing in the UK; a cross sectional survey. Benjamin P. Jones,Lorraine Kasaven,Ariadne L’Heveder,Maria Jalmbrant,Joy Green,Mahmoud Makki,Rabi Odia,Guy Morris,Timothy Bracewell Milnes,Srdjan Saso,Paul Serhal,Jara Ben Nagi. 2020
Preconception tests at advanced maternal age Best Practice & Research Clinical Obstetrics & Gynaecology. Srividya Seshadri; Guy Morris, P.Serhal and W.Saab s 10.1016/j.bpobgyn.2020.11.003. Part of ISSN: 1521-6934  2020
The Association Between Elevated Progesterone Level on Day of hCG Trigger and Live Birth Rates in ART Cycles: A Single Centre Observational Study. Shahin Robati, Wiam Saab, Montserrat Durán-Retamal; Wael Saab, Efstathios Theodorou; Suzanne Cawood; Paul Serhal; Srividya Seshadri 2020
Preconceptual care for couples seeking fertility treatment, an evidence-based approach. ElpinikiChronopoulou.AmeliaSeifalian.JudithStephenson.PaulSerhal.WaelSaab.Srividya Seshadri 2020
Effect of paternal age on outcomes in assisted reproductive technology cycles: systematic review and meta-analysis. G. Morris, D. Mavrelos, E. Theodorou,M. Campbell-Forde, D. Cansfield, E. Yasmin, P. Sangster, W. Saab, P. Serhal, S. Sehadri 2020
The novel use of fertility quality of life (FertiQoL) treatment subscale to assess treatment acceptability in social egg freezing. Benjamin Jones , Abirami Rajamanoharan , Lorraine Kasaven , Maria Jalmbrant , Joy Green , Makki Mahmoud , Rabi Odia , Srdjan Saso , Paul Serhal & Jara Ben Nagi. Human fertility 2020.
Systematic review and meta-analysis of prevalence of microbiota in ART cycles and recurrent pregnancy loss. S. Robati, S. Chronopoulou, E. Theodorou, P. Serhal, W. Saab, V. Seshadri. ESHRE 2020 Oral
Effect of paternal age on outcomes in ART cycles: A systemic review and meta-analysis. G. Morris, D. Mavrelos, E. Theodorou,M. Campbell-Forde, D. Cansfield, E. Yasmin, P. Sangster, W. Saab, P. Serhal, S. Sehadri. ESHRE 2020 Poster
Does sperm DNA fragmentation influence blastocyst ploidy? D. Mavrelos, B. Sowry, B. Jones, G. Morris, S. Lewis, J. Ben Nagi. ESHRE 2020 Poster
Next generation sequencing detects premeiotic erros in human oocytes and provides evidence of genetic influence. H. Ghevaria, S. Sen Gupta, R. Naja, R. Odia, P. Serhal, X. Vinals Gonzalez, X. Sun, J. Delhanty. ESHG 2020 Poster
IVF or ICSI-derived euploid blastocysts.
Z.Enakshi, X. Vinals-Gonzalez, V. Seshadri, W.Saab, R.Odia, S.Cawood, P.Serhal. Fertility 2020 Oral
Non-invasive chromosome screening reveals high concordance rate when using MALBAC technique for whole genome amplification for preimplantation genetic testing for aneuploidies.  R. Odia, J. Ben-Nagi X. Vinals-Gonzalez, B.Hensinger, J.Wang, P. Serhal  Fertility 2020 Oral
Use of intracytoplasmic morphologically selected sperm injection (IMSI) reduces risk of miscarriage and increases embryo utilisation in patients with high sperm DNA fragmentation index (DFI). Sowry, J.Ben-Nagi; P.Serhal, et al., Fertility 2020 Poster
Oocyte cytoplasmic maturation: Design, organisation and Synchrony. Vinals-Gonzalez1 , M.Gaunt, V. Seshadri, S.Gupta, et al., Fertility 2020 Poster
Live birth rate is associated with oocyte yield and number of biopsied and suitable blastocysts to transfer in preimplantation genetic testing (PGT) cycles for monogenic disorders and chromosomal structural rearrangements.   Jara Ben-Nagia, *, Benjamin Jonesb , Roy Najac , Ahmed Amera , Sesh Sunkarad , Sioban SenGuptae , Paul Serhal. EJOG 2019
Perceptions, outcomes and regret following social egg freezing in the UK; a cross-sectional survey.   Benjamin P. Jones; Lorraine Kasaven; Ariadne L’Heveder; Maria Jalmbrant; Joy Green; Mahmoud Makki; Rabi Odia; Guy Norris;Timothy Bracewell Milnes ;Srdjan Saso ; Paul Serhal; Jara Ben Nagi. Acta Obstetricia et Gynecologica Scandinavica 2019
Preimplantation genetic screening should be used in all in vitro fertilisation cycles in women over the age of 35 years: FOR: Optimising reproductive outcomes is cost‐effective and minimises adverse sequelae. Jara Ben Nagi; Paul Serhal; Dagan Wells; Benjamin P Jones BJOG 2019
Predictors of oocyte yield in social egg freezing. Green1, B. Jones2, A. Petrie3, G. Morris4, R. Odia5, P. Serhal6, J. Ben-Nagi6. ESHRE 2019
Effect of Antimullerian Hormone (AMH) on ploidy status after NGS-(PGT-A) and implantation.  Seshadri.V; W.Saab; Ozturk.O;  X. Vinals-Gonzalez; Odia,R; Cawood.S;  Serhal, P. ESHRE 2019 Oral
Effect of male age on ART outcomes. Morris.G; Seshadri.V; W.Saab. D.Mavrelous, P.Serhal ESHRE 2019 Oral Presentation
Model using a Comprehensive Algorithm of Reproductive Efficiency system to predict outcome of IVF cycles. X. Vinals-Gonzalez1, C. Heath1, O. Ozturk1, W. Saab2, V. Seshadri2, P. Serhal ESHRE 2019
Dynamics of  embryo multinucleation as an early predictor of euploidy status following PGT-A -Morphokinetic analysis.  Ahmed-Odia1, X. Vinals-Gonzalez1, C. Heath1, O. Ozturk1, W. Saab2, V. Seshadri2, P. Serhal2 ESHRE 2019 
Effect of Paternal age on ploidy status after NGS-(PGT-A). W; Seshadri.V; Cansfield.D; Heath.C; X. Vinals-Gonzalez; Odia. R.A; Serhal.P ESHRE 2019 
An overview of the nursing management and pathway of patients undergoing Intravenous Immunoglobulin infusion therapy (IVIg).  Steyn1, W. Saab2, V. Seshadri2, P. Serhal2, K.L. Wright1 ESHRE 2019
Perceptions, outcomes and regret following social egg freezing in the UK. Ben Nagi, J; Jones, B; Jalmbrant, M; Green, J; Rabi, O; Norris, G; Serha,l P. ESHRE 2019
The novel use of the Fertility Quality of Life (FertiQoL) treatment subscale in social egg freezers.   B Jones, M Jalmbrant, Joy Green, G Norris, R Odia, S Saso, Paul Serhal, J Ben Nagi. (2019)
Predictors of oocyte yield in women embarking on social egg freezing  B Jones, R Odia, J Green, A Petrie, G Norris, S Saso, P Serhal, J Ben Nagi. ESHRE 2019
Is oocyte maturity influenced by trigger type in oocyte donation cycles?  Jones , B; Al-Chami, A; Gonzalez, X; Arshad, Falak; Green, J; Bracewell-Milnes, T; Saso, S; Smith, R; Serhal, P; Ben Nagi, J. RCOG 2019
Euploid blastocysts implant irrespective of their morphology after preimplantation genetic testing-aneuploidy using next generation sequencing.    Viñals Gonzalez X., Odia R., Naja R., Serhal P., Saab W., Seshadri S., Ben Nagi J. PGDIS 2019 
The First ongoing Pregnancy Following Comprehensive Aneuploidy Assessment Using a Combined Blastocenetesis, Cell Free DNA and Trophectoderm Biopsy Strategy. Jara Ben-Nagi 1*, Rabi Odia 2, Xavier Viñals Gonzalez2, Carleen Heath2, Dhruti Babariya3, Sioban SenGupta4, Paul Serhal1, Dagan Wells 5. J Reprod Infertil. 2019;20(1):57-62
Live birth and miscarriage rate following intracytoplasmic morphologically selected sperm injection vs intracytoplasmic sperm injection: An updated systematic review and meta-analysis. Duran-Retamal M, Morris G, Achilli C, Gaunt M, Theodorou E, Saab W, Serhal P, Seshadri S.
Acta Obstet Gynecol Scand. 2019 Aug
In assisted reproduction by IVF or ICSI, the rate at which embryos develop to the blastocyst stage is influenced by the fertilization method used: a split IVF/ICSI study. Speyer B¹,², O’Neill H³Saab W4Seshadri S4Cawood S4Heath C4Gaunt M4Serhal P4
J Assist Reprod Genet. 2019 Jan 9. doi: 10.1007/s10815-018-1358-3. [Epub ahead of print]
Livebirth rate is associated with oocyte yield and number of biopsied and suitable blastocysts to transfer in preimplantation genetic diagnosis (PGD) cycles: a single center experience  Ben-Nagi, Jara, Amer, Ahmed. Odia, Rabi.  Serhal, Paul. BFS/ACE 2019
Live birth rate following double biopsy, vitrification and thaw of blastocysts undergoing pre-implantation genetic testing (PGT): a single centre experience BFS/ACE 2019
Comparison Of Genetic Analysis Between Blastocentesis and Trophectoderm Biopsy: A Preliminary Study  Odia, R.; Babariya, D.; Viñals Gonzalez, X.; Heath, C.; Sowry, B.; Cawood, S.; Serhal, P.; Ben-Nagi, J. BFS/ACE 2019
Time lapse imaging of embryos is useful in in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment: FOR: Time-lapse monitoring of embryos. Seshadri S¹Saab W¹Serhal P¹
BJOG. 2019 Jan;126(2):287. doi: 10.1111/1471-0528.15159. Epub 2018 Jul 27.
The role of immunotherapy in in vitro fertilization and recurrent pregnancy loss: a systematic review and meta-analysis. Achilli C¹Duran-Retamal M²Saab W²Serhal P²Seshadri S². Fertil Steril. 2018 Nov;110(6):1089-1100. doi: 10.1016/j.fertnstert.2018.07.004.
Social egg freezing should be offered to single women approaching their late thirties: FOR: Women should not suffer involuntary childlessness because they have not yet found a partner.

Jones BP1, Serhal P2, Ben-Nagi J2.(2018) BJOG 

Social Egg Freezing – Early is not always best

Jones BPSerhal PBen Nagi J. (2018). Acta Obstet Gynecol Scand. 

Social egg freezing should be offered to single women approaching their late thirties: FOR: Women should not suffer involuntary childlessness because they have not yet found a partner.

Jones BPSerhal PBen-Nagi J (2018). BJOG

A comparison of intramuscular progesterone and 17-alpha hydroxyprogesterone caproate in patients undergoing frozen embryo replacement transfer cycles

S Seshadri, W.Saab, R.Odia,  X Vinals, R Odia,  A Alchami, P Serhal, O.Ozkan. ASRM-Oral Presentation (2018). 

Local Endometrial injury before frozen-thawed embryo transfer (FTET) cycles? A review and meta-analysis

Theodorou E, Ben Nagi J, Ozturk O, Serhal P.
Poster 34th Annual Conference ESHRE July 2018 

Next Generation Sequencing Detects Meiosis I and Premeiotic Errors in Human oocytes.
Ghevaria H, SenGupta S, Naja R, Odia R, Serhal P, Sun X, Delhanty J. UCL EGA Institute for women’s health (UCL/CRGH) (2018)
Contraction behaviour reduces embryo competence in high quality euploid blastocysts (2018).
X.Vinals, R.Odia, S.Cawood, M.Gaunt, W.Saab, V.Seshadri, P.Serhal. Journal of Assisted Reproduction and Genetics.
Clinical outcomes of a vitrified donor oocyte programme: A single UK centre experience. Seshadri. W.Saab. H.Exeter E.Drew. A.Petrie M.Davies P.Serhal (2018).  European Journal of Obstetrics & Gynecology and Reproductive Biology
Screening hysteroscopy in subfertile women and women undergoing assisted reproduction.
Mohan S Kamath, Jan Bosteels, Thomas M D’Hooghe, Srividya Seshadri, Steven Weyers, Ben Willem J Mol, Frank J Broekmans, Sesh Kamal Sunkara. (2018) Cochrane Review 
Correlation between Embryo Ploidy Status and ovarian response after controlled ovarian Stimulation. Seshadri, Vidya; Viñals-Gonzalez, Xavier; Odia, Rabi; Saab, Wael; Cawood, Suzanne; Serhal, Paul.  Oral Presentation-Annual ESHRE Conference 2018-Barcelona.
Does embryonic culture environment affect ploidy rates? Odia, Rabi; Drew, Emily; Exeter, Holly; Viñals-Gonzalez, Xavier; Saab, Wael; Seshadri, Vidya; Cawood, Suzanne; Serhal, Paul. Poster Presentation- Annual ESHRE Conference 2018-Barcelona.
Era of frozen blastocyst embryo transfer might replace that of fresh blastocyst embryo transfer—A large retrospective cohort study. Saab, Wael; Seshadri, Vidya; Cawood, Suzanne; Heath, Carleen; Odia, Rabi; Sowry, Blair; Viñals-Gonzalez, Xavier; Serhal, Paul.  Poster Presentation- Annual ESHRE Conference 2018-Barcelona.
Fertility nursing education and career progression framework. F. Steyn, J. Wilson, F. Pringle, J. Denton, C. Bagness, H. Miller, Y. Wedden, A. Denga, K. Best, J. Mutch. Poster Presentation- Annual ESHRE Conference 2018-Barcelona. 
The dawn of a new ice age: social egg freezing.   Jones BP, Saso S, Mania A, Smith JR Serhal P, Ben Nagi J . (2018).  Journal of Acta Obstericia Gynecologica Scandinacia.
Impact of sperm DNA fragmentation on blastocyst development and clinical outcome. Sowry, B.; Viñals Gonzalez, X.; Cawood, S.; Seshadri, S.; Serhal, PPoster Presentation- Annual Joint BFS and ACE Annual Conference 2018
Does Type of Trigger Affect Oocyte Maturation in Altruistic Egg Donor Cycles? Arshad, Falak; Viñals Gonzalez, Xavier; Ben Nagi, Jara; Al Chami, Ali; Serhal, Paul. Poster Presentation- Annual Joint BFS and ACE Annual Conference 2018
Study of Fertilisation Dynamics and Clinical Outcome using Calcium Ionophore. Viñals Gonzalez, Xavier; Odia, Rabi; Cawood, Suzanne; Saab, Wael; Serhal Paul. Poster Presentation- Annual Joint BFS and ACE Annual Conference 2018
Livebirth rate from NC-IVF applied to women with poor ovarian reserve and/or history of diminished response to ovarian stimulation. Ben-Nagi, J.; Jones, B.; Alchami, A.; Drew, E. Exeter, H; Serhal, P. Poster Presentation- Annual Joint BFS and ACE Annual Conference 2018.
Does the use of calcium ionophore during artificial oocyte activation demonstrate an effect on pregnancy rate? A meta-analysis. Fertility and Sterility. Murugesu S, Saso S, Jones BP, Bracewell-Milnes T, Athanasiou T, Mania A, Serhal P, Ben-Nagi J (2017)
Karyomapping: a single centre’s experience from application of methodology to ongoing pregnancy and live-birth rates. Jara Ben-Nagi, Dagan Wells, Karen Doye, Kalliopi Loutradi, Holly Exeter, Emily Drew, Samer Alfarawati , Roy Naja, Paul Serhal. (2017)  Reproductive Biomedicine online. 
Study of Embryo Surface Variation and Contraction Pattern as Potential Predictors of Embryo Chromosomal Content. Viñals Gonzalez,X.;Mania,A.; Doshi,A.; Loutradi,K.; Seshadri,SV.; Serhal, P.  Oral Presentation-Annual ESHRE Conference 2017-Geneva
Is there a role for immunotherapy in IVF and recurrent miscarriage: a systematic review and meta-analysis. C.Achilli, W.Saab, M.Duran, K.Sunkara, P.Serhal.  Oral Presentation- ESHRE Annual Conference 2017-Geneva
Could embryo banking be used as a treatment strategy in the management of poor responders? H. Exeter. V. Seshadri. E. Drew. A. Petrie. P.Serhal.  Poster Presentation- ESHRE Annual Conference 2017-Geneva
Analysis of embryo morphokinetics as a probable predictive variable of euploid embryos by time-lapse monitoring technique. Duran, M.; Vinals Gonzalez, X.; Brunetti, X.; Ben Nagi, J.; Al Chami, A.; Saab, W.; Seshadri, SV.; Serhal, P.  Poster Presentation- ESHRE Annual Conference 2017-Geneva 
IMSI does not improve misc rate for patient with recurrent implantation failure and/or male factor infertility. Duran, Montserrat; Seshadri, Vidya; Doshi, Alpesh; Loutradi, Kalliopi; Saab, Wael; Cawood, Suzanne; Mania, Anastasia; Sarna, Urvashi; Gaunt, Matthew; Heath, Carleen; Odia, Rabi; Achilli, Chiara; Serhal, PaulOral Presentation: 2nd World Congress of pregnancy Loss: Jan 2017.
Intracytoplasmic Morphologically selected sperm injection does not improve neither miscarriage rate nor live birth rate in patients with recurrent implantation failure and/or male factor. Duran, Montserrat; Seshadri, Vidya; Doshi, Alpesh; Loutradi, Kalliopi; Saab, Wael; Cawood, Suzanne; Mania, Anastasia; Sarna, Urvashi; Gaunt, Matthew; Heath, Carleen; Odia, Rabi; Achilli, Chiara; Serhal, Paul. Poster Presentation-British Fertility Society and ACE Annual Conference 2017
Ongoing clinical pregnancy following ICSI of late metaphase II oocyte for PGD-BRCA1 Odia.Rabi, Loutradi.Kalliopi, Heath.Carleen, Cawood.Suzzane, Doshi.Alpesh. Ozturk.Ozkan and Serhal.Paul. Poster Presentation-The Association of Clinical  Embryologists (ACE) Jan 2017 Annual Conference
A retrospective case series of clinical application of karyomapping for couples requiring preimplantationgenetic diagnosis. Ben-Nagi J., Doye K, Wells D, Exeter H, Drew W, Serhal P. : ESHRE 2016, Helsinki
Trophectoderm biopsy and transfer in a subsequent frozen thaw embryo replacement cycle in preimplantation genetic diagnosis cycles. Karen Doye, Jara Ben Nagi, Kalliopi E. Loutradi, Emily Drew, Holly Exeter, Paul Serhal: ESHRE 2016, Helsinki Download here
Preconceptual health and fertility treatment – an evidence based approach. E. Chronopoulou1 , P Serhal, S. Seshadri: ESHRE 2016, Helsinki
Outcomes of blastocyst transfer using vitrified donor oocytes. W Saab, S Seshadri, M Davies, A Petrie, H Exeter, P Serhal:  ESHRE 2016, Helsinki
Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer. Wuntakal R, SeshadriS, Montes A, Lane G. CochraneDatabaseof SystematicReviews 2016, Issue 6. Art. No.: CD011322. DOI: 10.1002/14651858.CD011322.pub2.
Preimplantation genetic diagnosis: an overview and recent advances. Ben-Nagi J, Serhal P, SenGupta S, Doye K, Wells D. Preimplantation genetic diagnosis: an overview and recent advances. The Obstetrician & Gynaecologist 2016;18:99106. DOI:10.1111/tog.12264
The origin and significance of additional aneuploidy events in couples undergoing preimplantation genetic diagnosis for translocations by array comparative genomic hybridization. Ghevaria H, SenGupta S, Shmitova N, Serhal P, Delhanty J: Reproductive biomedicine online 32.2 (2016): 178-189.
Effect of progesterone levels on clinical pregnancy rates in IVF/ICSI cycles. S Seshadri, M Bhargava, A Doshi, W Saab, P serhal: BFS Annual Meeting 2016, Gateshead
Report of a Viable Pregnancy Arising from a Zygote with a Single Pronucleus at 16 Hours Post Inseminatation. Hema Sarna, Alpesh Doshi, Suzanne Cawood, Urvashi Sarna, Anastasia Mania, Rabi Odia, Paul Serhal. Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here
Data Analysis to Determine Whether There is an Association Between the Day of Blastocyst Formation and Sex Ratio. Hema Sarna, Paul Serhal, Kalliopi Loutradi, Anastasia Mania and Ozkan Ozturk.  Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here
Does Multinucleation Correlate to Direct and Reverse Cleavage in Day 2 Cleavage Stage Embryos? A Time-lapse Analysis. A. Mania, L. Papaioannou, V. Wigley, U. Sarna, C. Heath, S. Gotts, K. Loutradi, A. Doshi, W. Saab, P. Serhal. Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here
Should cryopreservation of sperm be routinely offered to Klinefelter’s patients? Emily Drew, Suzanne Cawood, Alpesh Doshi, Paul Serhal. Presentation: The Association of Clinical Embryologists (ACE) 2016 Annual Conference. Download Here
Investigation of microRNA expression and DNA repair gene transcripts in human oocytes and blastocysts. Tulay, P., Naja, R. P., Cascales-Roman, O., Doshi, A., Serhal, P., & SenGupta, S. B. (2015). Journal of assisted reproduction and genetics32(12), 1757-1764.
Successful outcomes achieved in assisted reproduction cycles using sperm with high levels of high DNA stainability. Speyer, B. E., Pizzey, A. R., Abramov, B., Saab, W., Doshi, A., Sarna, U., … & Serhal, P. (2015).Systems biology in reproductive medicine61(5), 293-299.
Karyomapping: A novel alternative approach to PGD. S Seshadri, J Ben Nagi, K Doye, W Saab, A Doshi, D Wells, P Serhal:  ESHRE 2015, Lisbon
Adequate luteal support in Frozen embryo transfer cycles: Natural or Artificial Intramuscular progesterone?  A Al-Chami, S Salim, H Skye, A Doshi, W Saab, S Seshadri, P Serhal: BFS Annual Meeting 2015, Birmingham
Telomere length in human blastocysts. Mania, A., Mantzouratou, A., Delhanty, J. D., Baio, G., Serhal, P., & Sengupta, S. B. (2014). Reproductive biomedicine online28(5), 624-637.
Factors influencing the outcome of intrauterine insemination (IUI): age, clinical variables and significant thresholds. Speyer BE, Abramov B, Saab W, Doshi A, Sarna U, Harper JC, Serhal P.; Obstet Gynaecol. 2013 Oct;33(7):697-700. doi: 10.3109/01443615.2013.810199.
Role of Insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries. Stubbs SA, Webber LJ, Stark J, Rice S, Margara R, Lavery S, Trew GH, Hardy K, Franks S. J Clin Endocrinol Metab. 2013 Aug;98(8):3298-305. doi: 10.1210/jc.2013-1378.
Hepcidin levels in diabetes mellitus and polycystic ovary syndrome. Sam AH, Busbridge M, Amin A, Webber L, White D, Franks S, Martin NM, Sleeth M, Ismail NA, Daud NM, Papamargaritis D, Le Roux CW, Chapman RS, Frost G, Bloom SR, Murphy KG. Diabet Med. 2013 Dec;30(12):1495-9. doi: 10.1111/dme.12262.
Prepregnancy care. Seshadri S, Oakeshott P, Nelson-Piercy C, Chappell LC. BMJ. 2012 May 31;344:e3467. doi: 10.1136/bmj.e3467.
Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters. Joharatnam J, Barber TM, Webber L, Conway GS, McCarthy MI, Franks S. Clin Endocrinol (Oxf). 2011 Jun;74(6):714-9
The importance of the early uterine environment on obstetric outcome in ART treatments. Cawood S, Harper J, Serhal P, Joshi R, Doshi A. (2011). 6th Institute for Women’s Health, UCL.
Data analysis of patients suitable for elective single embryo transfer: why are patients refusing? Cawood S, Gotts S, Harper J, Serhal P, Doshi A. (2011) P33 6th Institute for Women’s Health, UCL.
Does assisted hatching improve the clinical outcome in vitrified-warmed embryo cycles? Cawood S, Doshi A, Gotts S, Serhal P. (2011). Fertility 2011, 5th-7th January/ Reproductive BioMedicine Online 20 Suppl. 2 (2010) S47–S49. Abstract FC-4 Alpha 2010, 8th Biennial conference, Budapest, Hungary, 30th April-2nd May.
A clinical pregnancy after transfer of a single vitrified warmed blastocyst derived from a donor vitrified-warmed oocyte. Cawood S, Doshi A, Serhal P, Harper J. (2011). P109 Fertility 2011, 5th-7th January.
Vitrified vs. slow-frozen blastocysts: A clinical audit for 706 embryos. Cawood S, Doshi A, Gotts S (2010). Reproductive BioMedicine Online 20 Suppl. 2 (2010) S47–S49. Abstract FC-2 Alpha, 2010, 8th Biennial conference, Budapest, Hungary, 30th April-2nd May/ Hum. Reprod. 25 (suppl 1): i170-i210. Abstract of the 26th Annual Meeting of the European Society of Human Reproduction and Embryology, Rome, Italy, 27-30 June.
Infertility (The Facts). Oxford University Press, 2009
Melanie Davies, Lisa Webber, Caroline Overton
Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries. Franks S, Webber LJ, Goh M, Valentine A, White DM, Conway G, Wiltshire S & McCarthy M J Clin Endocrinol Metab. 2008 Sept; 93: (9) 3396-3402
Response to controlled ovarian stimulation and oocyte quality in women with myotonic dystrophy type I. Journal of Assisted Reproduction Genetics. Vol 25 (Issue 1): pp 1-5, B Sahu, O Ozturk, N Deo, K Fordham, DM Ranieri, P Serhal (2008)
Comparison of oocyte quality and intracytoplasmic sperm injection outcome in women with isolated polycystic ovaries or polycystic ovarian syndrome. Archives Gynecology Obstetrics. Vol 277 (Number 3) : pp 239-44
B Sahu, O Ozturk, DM Ranieri, P Serhal (2008)
Evaluation of the relationship between follicular fluid oxidative stress, ovarian hormones, and response to gonadotropin stimulation. Fertility and Sterility. Vol. 89 (issue 4) : pp 912-21 M Appasamy, E Jauniaux, P Serhal, A Al-Qahtani, NP Groome, S Muttukrishna (2008)
Prolonged survival in culture of preantral follicles from polycystic ovaries. Webber LJ, Stubbs SA, Stark J, Margara RA, Trew GH, Lavery SA, Hardy K, Franks S. J Clin Endocrinol Metab. 2007 May;92(5):1975-8. Epub 2007 Mar 6.
Disordered follicle development in ovaries of prenatally androgenized ewes. Forsdike RA, Hardy K, Bull L, Stark J, Webber LJ, Stubbs S, Robinson JE, Franks S. J Endocrinol. 2007 Feb;192(2):421-8.
Preimplantation genetic diagnosis for myotonic dystrophy type 1 in the UK. Neuromuscular Disorders , Vol 18 (Issue 2) : pp 131 – 136
G Kakourou, S Dhanjal, T Mamas, S Gotts, A Doshi, K Fordham, P Serhal, DM Ranieri, JD Delhanty, JC Harper, SB SenGupta (2007)
Variable aneuploidy mechanisms in embryos from couples with poor reproductive histories undergoing preimplantation genetic screening. Human Reproduction. Vol 22 (issue 7) : pp 1844-53 A Mantzouratou, A Mania, E Fragouli, L Xanthopoulou, S Tashkandi, K Fordham, DM Ranieri, A Doshi, S Nuttall, JC Harper, P Serhal, JD Delhanty (2007)
Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility. Reproductive Biomedicine Online. Feb;14(2):159-65. M Appasamy, S Muttukrishna, AR Pizzey, O Ozturk, NP Groome, P Serhal, E Jauniaux (2007)
Preimplantation genetic diagnosis for retinoblastoma predisposition British Journal of Ophthalmology 91: 1090-1091 S Dhanjal, G Kakourou, T Mamas, N Saleh, A Doshi, S Gotts, S Nuttall, K Fordham, P Serhal, J Delhanty, JC Harper and S SenGupta (2007)
Preimplantation Genetic Diagnosis for myotonic dystrophy type 1: detection of cross-over between the gene and the linked marker AP0C2. Prenatal Diagnosis, 27 (2): 111-116 G Kakourou, S Dhanjal, Daphnis, A Doshi, S Nuttall, S Gotts, P Serhal, J Delhanty, JC Harper, and S SenGupta (2007)
Variations in Humanized and Defined Culture Conditions Supporting Derivation of New Human Embryonic Stem Cell Lines. Cloning and Stem Cells. December 1, 2006, 8(4): 319-334. doi:10.1089/clo.2006.8.319. Judy M. Fletcher, Patricia M. Ferrier, John O. Gardner, Linda Harkness, Seema Dhanjal, Paul Serhal, Joyce Harper, Joy Delhanty, David G. Brownstein, Yogesh R. Prasad, Jane Lebkowski, Ram Mandalam, Ian Wilmut, Paul A. De Sousa
Comparative Genomic Hybridisation analysis of human occytes and polar bodies. Human Reproduction 21: 2319-2328. E Fgagouli, D Wells, A Thornhill, P Serhal, MJW Faed, JC Harper, JDA Delhanty (2006)
Anti-Mullerian hormone (AMH) protein expression is reduced during the initial stages of follicle development in human polycystic ovaries S Stubbs, K Hardy, P Da Silva-Buttkus, J Stark, LJ Webber, A Flanagan, APN Themmen, JA Visser, NP Groome, & S Franks
Journal of Clinical Endocrinology & Metabolism 2005 Oct 90(10):5536-5543
Antral Follicle count,anti-mullerian hormone and inhibinB: predictors of ovarian response in assisted reproductive technology? S. Muttukrishmna, H. McGarrigle, R. Wakim, I. Khadum, D.M. Ranieri and P. Serhal. BJOG , Vol.112,.2005
Good Clinical Practice in Assisted Reproduction: Ed. Paul Serhal and Caroline Overton. Camb. Univ.Press. 2004.
Formation and early development of follicles in the polycystic ovary LJ Webber, S Stubbs, J Stark, GH Trew, R Margara, K Hardy & S Franks, The Lancet 2003; 362:1017-1021
Cervical dilatation with hygroscopic rods prior to ovarian stimulation facilitates embryo transfer. Paul Serhal, Domenico Massimo Ranieri, Iffat Khadum and Rami Antoine Wakim. Human Reproduction, Vol. 18, No.12 pp 2618-2620, 2003.
Preimplantation genetic diagnosis of chromosome abnormalities: implications from the outcome for couples with chromosomal rearrangements.  M.Simopoulou, J.C.Harper, E.Fragouli, A.Mantzouratou, B.E.Speyer, P.Serhal, D.M.Ranieri, A.Doshi, J.Henderson, C.H.Rodeck and J.D.A.Delhanty. Prenat.Diagn. 2003: 23: 652-662.
Cytogenetic and Y chromosome microdeletion screening of a random group of infertile males. C.R. Quilter, E.C. Svennevik, P. Serhal, D. Ralph, G. Bahadur, R. Stanhope, M. Sutterlin, J. Delhanty and K.E. Taylor. Fertility and Sterility Vol. 79 No. 2 February 2003.
A comparative study between infertile males and patients with Turner Syndrome to determine the influence of sex chromosome mosaicism and the breakpoints of structurally abnormal Y chromosomes on phenotypic sex. C.R. Quilter, N. Nathwani, G.S.Conway, R.Stanhope, D. Ralph, G. Bahadur, P. Serhal, K. Taylor and J.D.A. Delhanty. Journal of Medical Genetics 2002; 39; e80-e80.
Ovarian response and in vitro fertilisation outcome in patients with reduced ovarian reserve who were stimulated with recombinant follicle-stimulating hormone or human menopausal gonadotropin. F. Meo, D.M. Ranieri, I. Khadum, P. Serhal. Fertility & Sterility Vol. 77 No. 3. March 2002.
First application of preimplantation genetic diagnosis to neurofibromatosis type 2 (NF2) Abou-Sleiman P MN, Apessos A, Harper JC, Serhal P, Winston R M, Delhanty J. Prenat. Diagn. 2002 Jun; 22 (6): 519-24.
PGD for Single Gene Disorders: Experience with five single gene disorders, myotonic dystrophy, two mutations for cystic fibrosis, simultaneous diagnosis of fragile X and CF, Crouzon Syndrome and Neurofibromatosis type 2 Prenatal Diagnosis, 22 (6): 525-533 Joyce C. Harper, Dagan Wells, Wirawit Piyamongkol, Patrick Abou-Sleiman, Angela Apessos, Antonis Ioulianis, Mary Davis, Alpesh Doshi, Paul Serhal, Massimo Ranieri, Charles Rodeck and Joy D.A. Delhanty (2002)
Preimplantation Genetics and Diagnosis Paper First application of preimplantation genetic diagnosis to neurofibromatosis type 2 (NF2)
P. M. Abou-Sleiman, A. Apessos, J. C. Harper , P. Serhal, R. M. L. Winston , J. D. A. Delhanty (2002)
Pregnancy Following Preimplantation Genetic Diagnosis for Crouzon Syndrome. P.M. Abou-Sleiman, A. Apessos, J.C. Harper, P.Serhal and J.D.A. Delhanty. Molecular Human Reproduction, 8, 101-104. 2002. 
Pregnancy Following Preimplantation Genetic Diagnosis for Crouzon Syndrome. P.M. Abou-Sleiman, A. Apessos, J.C. Harper, P.Serhal and J.D.A. Delhanty. Molecular Human Reproduction, 8, 101-104. 2002.
A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR. W. Piyamongkol, J.C. Harper, J.K. Sherlock, A. Doshi, P.F. Serhal, J.D.A. Delhanty and D. Wells. Prenat Diagn 2001; 21: 223-232.
Simultaneous evaluation of basal FSH and oestradiol response to GnRH analogue (G-G-Test) allows effective drug regimen selection for IVF. D.M.Ranieri, P.Phophong, I. Khadum, F. Meo, C. Davis and P.Serhal. Human Reprod. 2001 Vol. 16 No.4 pp 673-675.
Clinical aspects of preimplantation diagnosis. C.Overton, P.Serhal, M.Davies Chapter in Preimplantation Genetic Diagnosis. Eds.: J. Harper, J.Delhanty and A.Handyside. 2001
Basal 17 B-estradiol did not correlate with ovarian response and in vitro fertilization treatment outcome. P.Phophong, d.M. Ranieri, I. Khadum, F. Meo, and P. Serhal. Fertility & Sterility Vol. 74 No. 6 2000. pp 1133-36
FISH analysis on day 5 post-insemination of human arrested and blastocyst stage embryos. P.Ruangvutilert, J.D.A. Delhanty, P. Serhal, Mara Simopoulou, Charles H. Rodeck and Joyce C. Harper. Prenat Diagn 2000: 20: 552-560
Ovarian reserve: A simple mathematical problem? D.M.Ranieri, P.Serhal. Human. Reprod. 2000. 15: 1423-4.

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